Photodynamische Therapie: Kombination verbessert das medizinische und ästhetische Ergebnis auf lichtgeschädigter Haut

Objective:To evaluate the efficacy and safety of photodynamic therapy (PDT) with the novel 10% aminolevulinic acid (ALA) hydrochloride gel (10% ALA gel) and BF-RhodoLED® light (635 nm; 37 J/cm 2 ) in combination with intense pulsed light (IPL) to augment the medical and aesthetic improvement of phot...

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Bibliographic Details
Published inKarger Kompass Dermatologie Vol. 10; no. 4; pp. 191 - 192
Main Author Schulz, Andrea
Format Journal Article
LanguageEnglish
German
Published Freiburg, Germany 01.12.2022
Subjects
Wissenstransfer
Chest
Otodamageph
Otodynamic therapyre
Ameluz
IPL
Décolletéip
Rejuvenation
BF-RhodoLED
Aminolevulinic acid
Tph
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Summary:Objective:To evaluate the efficacy and safety of photodynamic therapy (PDT) with the novel 10% aminolevulinic acid (ALA) hydrochloride gel (10% ALA gel) and BF-RhodoLED® light (635 nm; 37 J/cm 2 ) in combination with intense pulsed light (IPL) to augment the medical and aesthetic improvement of photodamaged skin of the décolleté. Methods:This was a single-site prospective, randomized, intraindividual split chest pilot study with 20 female subjects with moderate to severe photodamage of the décolleté. Subjects were randomized to ALA-PDT + IPL to one split-side of the chest and ALA-PDT only to the contralateral side. Three blinded raters assessed aesthetic improvement using the global aesthetic improvement scale (GAIS). Results:Eighteen subjects completed the study. Superior GAIS results were achieved on the ALA-PDT + IPL treatment side than on the ALA-PDT only treatment side (p < 0.001) after 24 weeks of follow-up. Conclusions:ALA-PDT using 10% ALA hydrochloride gel and BF-RhodoLED® light had superior rejuvenation effects on the décolleté when combined with IPL compared to ALA-PDT alone.
ISSN:2296-5424
2296-536X
DOI:10.1159/000527658