MORPHOFUNCTIONAL CHARACTERISTICS TESTES WISTAR RATS EXPOSED TO LPS IN GIPERANDROGENEMII

We investigated the morphological changes of the testes of Wistar rats with acute gram-negative ENDOTOXICOSIS against giperandrogenemii. In acute ENDOTOXICOSIS 1 st day after injection of lipopolysaccharide (LPS) showed a reduction in the level of total testosterone in serum, increase of Leydig cell...

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Published inI.P. Pavlov Russian Medical Biological Herald Vol. 19; no. 2; p. 5
Main Authors Vasil'eva, Svetlana Gennad'evna, Mkhitarov, V A, Kosyreva, A M, Makarova, O V, Vassilievа, S G, Kosyrevа, A M, Makarovа, O V
Format Journal Article
LanguageEnglish
Published 15.06.2011
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Abstract We investigated the morphological changes of the testes of Wistar rats with acute gram-negative ENDOTOXICOSIS against giperandrogenemii. In acute ENDOTOXICOSIS 1 st day after injection of lipopolysaccharide (LPS) showed a reduction in the level of total testosterone in serum, increase of Leydig cell nuclei and the diameters of the convoluted tubules, on the 7 th day, these figures were normalized. The introduction of LPS against giperandrogenemii recorded the most pronounced morphological changes, including significant reduction in the index of spermatogenesis, which reflects the suppression of spermatogenic function.
AbstractList We investigated the morphological changes of the testes of Wistar rats with acute gram-negative ENDOTOXICOSIS against giperandrogenemii. In acute ENDOTOXICOSIS 1 st day after injection of lipopolysaccharide (LPS) showed a reduction in the level of total testosterone in serum, increase of Leydig cell nuclei and the diameters of the convoluted tubules, on the 7 th day, these figures were normalized. The introduction of LPS against giperandrogenemii recorded the most pronounced morphological changes, including significant reduction in the index of spermatogenesis, which reflects the suppression of spermatogenic function.
Author Vasil'eva, Svetlana Gennad'evna
Kosyrevа, A M
Makarovа, O V
Vassilievа, S G
Mkhitarov, V A
Kosyreva, A M
Makarova, O V
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Cites_doi 10.1210/endo.141.1.7240
10.1080/13625180600699548
10.1007/BF02738619
10.1016/S0950-351X(98)80248-6
10.1186/1477-7827-5-11
10.1007/978-3-642-02155-8
10.1016/S0950-351X(98)80210-3
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