Streptococcus pneumoniae and Influenza (H1N1) Virus Genome Study against Human Genome Sequences-BLASTn and DAVID Analysis

• Published in: South East European Journal of Immunology Vol. 7; pp. 67 - 80
• Main Authors: Arokiaraj, Mark Christopher, Wilson, Jarad, Lu, Jingquio, Huang, Ruo-Pan
• Format: Journal Article
• Language: English
• Published: 30.05.2024
• ISSN: 1857-9388; 1857-9388
• DOI: 10.3889/seejim.2024.6064

AIMS: Streptococcus pneumoniae and influenza H1N1 virus are common organisms associated with human infections. These infections could play a significant role in immune regulation. The study was performed to analyze the genome sequences of these organisms with human genome and study its functional significance. MATERIALS AND METHODS: The study was performed to analyze the overlapping of genome sequences in S.pneumoniae and influenza (H1N1) virus against human genome sequences by BLASTn sequence analysis. The alignments are studied against the corresponding genes for their functional significance with DAVID and NDEx software. RESULTS: Several hits or overlapping nucleotide segments were identified. Between streptococcus and Homo Sapiens 287 overlaps were identified, and among influenza and Homo sapiens 124 hits were identified. A wide range of functional significance of these genes were identified, and the results are presented in this study. The results show insights into functional pathways and biological activities associated with the respective vaccinations or infections by these microorganisms. CONCLUSION: The common organisms such as S. pneumoniae and influenza H1N1 virus actively interact with the immune system and result in a wide range of immune regulations.