Poids de naissance et transfert d’embryon congelé : état de l’art

The aim of this study was to update our acknowledgment if there is a link between assisted embryo cryopreservation and epigenetics in human? Animal studies have demonstrated epigenetics consequence and especially imprinting disorders due to in vitro culture. In human, it is important to note that af...

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Published inGynécologie, obstétrique, fertilité & sénologie Vol. 46; no. 5; pp. 489 - 496
Main Authors Anav, M., Ferrières-Hoa, A., Gala, A., Fournier, A., Zaragoza, S., Vintejoux, E., Vincens, C., Hamamah, S.
Format Journal Article
LanguageFrench
Published Elsevier 01.05.2018
Subjects
Gynecology and obstetrics
Human health and pathology
Life Sciences
Épigénétique
Frozen embryo transfer
ART
Poids de naissance
AMP
Birth weight
Crypreservation
Epigenetic
Transfert d’embryon congelé
Cryopréservation
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Summary:The aim of this study was to update our acknowledgment if there is a link between assisted embryo cryopreservation and epigenetics in human? Animal studies have demonstrated epigenetics consequence and especially imprinting disorders due to in vitro culture. In human, it is important to note that after frozen embryo transfer birth weight is significantly increased by 81 to 250g. But these studies cannot identify the reasons of such difference. This review strongly suggests that embryo cryopreservation is responsible for birth weight variations but mechanisms not yet elucidated. Epigenetics is probably one of these but to date, none study is able to prove it. We have to be attentive on a possible link between assisted reproductive technology (ART) and epigenetics reprogrammation.
ISSN:2468-7197
2468-7189
DOI:10.1016/j.gofs.2018.03.012