Pramipexole protective effect on rotenone induced neurotoxicity in mice

Abstract Introduction:Pramipexole is a new dopaminergic drug which has been approved for PD treatment. However, we tried to find a new capacity for this drug rather than symptomatic effect. Materials and Methods: A chronic rotenone model with daily oral dose of 30mg/kg was induced in mice. Pramipexo...

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Published inNature precedings
Main Authors Gad-Elhak, Seham, Salama, Mohamed, El-Tantawy, Dina, El-Dakroury, Sahar, Abd-Elghaffar, Hasan, El-Dosouky, Sara, Ghanem, Abdelaziz
Format Journal Article
LanguageEnglish
Published 22.11.2011
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Summary:Abstract Introduction:Pramipexole is a new dopaminergic drug which has been approved for PD treatment. However, we tried to find a new capacity for this drug rather than symptomatic effect. Materials and Methods: A chronic rotenone model with daily oral dose of 30mg/kg was induced in mice. Pramipexole was tried in a new approach where the treatment began in the middle of rotenone course with oral dose 1mg/kg/day of pramipexole. Results: Further analysis of behavioral tests and immunohistochemistry revealed success of pramipexole in improving the rotenone intoxicated mice. Conclusion: These results showed possible beneficial effects of pramipexole against rotenone-induced neurotoxicity.
ISSN:1756-0357
1756-0357
DOI:10.1038/npre.2011.6640.1