不同弹性模量人工软骨对缺损软骨修复区细胞力学环境影响的研究
应用有限元软件COMSOL建立关节软骨固液双相模型和细胞微观模型，跨尺度研究在生理载荷作用下不同弹性模量的人工软骨修复缺损时，宿主软骨各层细胞的力学环境和液相流场。模拟结果表明，均一弹性模量的人工软骨对不同层区细胞微环境的影响规律不同。随着人工软骨弹性模量增大，浅表层、中间层细胞应力增大，深层细胞应力减小。人工软骨植入改变了中间层、底层软骨的流场方向和营养供给方式，可能会造成软骨细胞营养供应障碍。上述影响可造成修复结果不确定。通过对跨尺度软骨细胞有限元模型进行仿真分析，可定量地评价宿主软骨各层细胞的力学环境，有助于更准确地评估软骨缺损修复的临床效果。...
Saved in:
| Published in | Sheng wu yi xue gong cheng xue za zhi Vol. 34; no. 1; pp. 34 - 40 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese English |
| Published |
中国四川
四川大学华西医院
25.02.2017
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Summary: | 应用有限元软件COMSOL建立关节软骨固液双相模型和细胞微观模型，跨尺度研究在生理载荷作用下不同弹性模量的人工软骨修复缺损时，宿主软骨各层细胞的力学环境和液相流场。模拟结果表明，均一弹性模量的人工软骨对不同层区细胞微环境的影响规律不同。随着人工软骨弹性模量增大，浅表层、中间层细胞应力增大，深层细胞应力减小。人工软骨植入改变了中间层、底层软骨的流场方向和营养供给方式，可能会造成软骨细胞营养供应障碍。上述影响可造成修复结果不确定。通过对跨尺度软骨细胞有限元模型进行仿真分析，可定量地评价宿主软骨各层细胞的力学环境，有助于更准确地评估软骨缺损修复的临床效果。 |
|---|---|
| Bibliography: | A solid-liquid two-phase finite element model of articular cartilage and a microscopic finite element model of chondrocytes were established using the finite element software COMSOL in this study. The purpose of the study is to investigate the mechanics environment and the liquid flow field of the host cartilage chondrocytes in each layer by multi-scale method, under physiological load, with the different elastic modulus of artificial cartilage to repair cartilage defect. The simulation results showed that the uniform elastic modulus of artificial cartilage had different influences on the microenvironment of different layer chondrocytes. With the increase of the elastic modulus of artificial cartilage, the stress of the shallow surface layer and the intermediate layer chondrocytes increased and the stress of deep layer chondrocytes decreased. The flow field direction of the middle layer and the bottom layer of cartilage can also be changed by artificial cartilage implantation, as well as the ways of nourishme |
| ISSN: | 1001-5515 |
| DOI: | 10.7507/1001-5515.201605002 |