Genomic Imprinting: A New Epigenetic Perspective of Sleep Regulation

[...]sleep loss disrupts the circadian rhythm in 20% of the oscillating genes in the brain [2] and affects the DNA binding of clock genes by acting on the methylation state of their promoters [3]. [...]significant methylation changes have recently been reported in mice when their sleep-wake cycles a...

Full description

Saved in:
Bibliographic Details
Published inPLoS genetics Vol. 12; no. 5; p. e1006004
Main Author Tucci, Valter
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 26.05.2016
Public Library of Science (PLoS)
Subjects
Biology and Life Sciences
Chromosomes
Circadian rhythm
Cognition & reasoning
Epigenetic inheritance
Epigenetics
Eye movements
Funding
Gene expression
Genetic aspects
Genetic engineering
Medicine and Health Sciences
Metabolism
Observations
Physiology
Prenatal development
Sleep
Sleep deprivation
Studies
Theory
Viewpoints
Online AccessGet full text

Cover

More Information
Summary:[...]sleep loss disrupts the circadian rhythm in 20% of the oscillating genes in the brain [2] and affects the DNA binding of clock genes by acting on the methylation state of their promoters [3]. [...]significant methylation changes have recently been reported in mice when their sleep-wake cycles are manipulated starting in the early stages of development after birth [4]. Sleep is the most substantial state during development (i.e., it occupies two-thirds of the day in newborns) and plays a fundamental role in developmental processes; furthermore, genomic imprinting is crucial for growth, development, and neurogenesis [10,48]. [...]investigations focusing on the interplay between sleep and specific developmental genomic imprinting mechanisms may reveal important new avenues for investigating the neurodevelopmental mechanisms of sleep.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
The author has declared that no competing interests exist.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1006004