Comparison of Prognostic miRNA Signature in Patients with Acute and Chronic Myeloid Leukemia by Bioinformatic Analysis

• Published in: Medical Records Vol. 4; no. 3; pp. 447 - 453
• Main Author: KARADAĞ, Aynur
• Format: Journal Article
• Language: English
• Published: 22.09.2022
• ISSN: 2687-4555; 2687-4555
• DOI: 10.37990/medr.1118392

Aim: In this study, differentially expressed miRNA profiles were determined using high-throughput expression data from samples of AML and CML patients to identify miRNAs involved in the therapeutic response. Material and Methods: miRNA microarray datasets GSE142699 and GSE90773 were downloaded via the GEO database and analysis was performed with the online analysis tool GEO2R. Data no. GSE142699 was made with 24 control and 24 newly diagnosed AML patients, data no. GSE90773 was made with 8 control and 10 newly diagnosed CML patients. After the analysis, they were grouped according to fold change (FC) values and p Amaç: Bu çalışmada, terapötik yanıtta yer alan miRNA’ları belirlemek için AML ve KML hastalarının örneklerinden alınan yüksek verimli ekspresyon verilerini kullanarak diferansiyel miRNA ekspresyonunu analiz ettik. Materyal ve Metot: miRNA mikrodizi veri setleri GSE142699 ve GSE90773, GEO veritabanı aracılığıyla indirildi ve çevrimiçi analiz aracı GEO2R ile analizi yapıldı. GSE142699 nolu data, 24 kontrol ve 24 yeni teşhis edilmiş AML hastası, GSE90773 nolu data ise 8 kontrol ve 10 yeni tanı konmuş KML hastası ile yapılmıştır. Analiz sonrası kat değişimi (FC) değerlerine ve p