Sonochemical synthesis of 5-substituted 1 H -tetrazoles catalyzed by ZrP 2 O 7 nanoparticles and regioselective conversion into new 2,5-disubstituted tetrazoles

Abstract The ultrasound-assisted preparation of 2-(1 H -tetrazol-5-yl) acrylonitrile derivatives via a one-pot multi-component method is described successfully using ZrP 2 O 7 nanoparticles as a catalyst. Readily available tetrazoles can be transformed into the corresponding 1,5- and 2,5-disubstitut...

Full description

Saved in:
Bibliographic Details
Published inZeitschrift für Naturforschung. B, A journal of chemical sciences Vol. 70; no. 11; pp. 819 - 828
Main Authors Safaei-Ghomi, Javad, Paymard-Samani, Soleiman, Zahedi, Safura, Shahbazi-Alavi, Hossein
Format Journal Article
LanguageEnglish
Published 01.11.2015
Online AccessGet full text

Cover

More Information
Summary:Abstract The ultrasound-assisted preparation of 2-(1 H -tetrazol-5-yl) acrylonitrile derivatives via a one-pot multi-component method is described successfully using ZrP 2 O 7 nanoparticles as a catalyst. Readily available tetrazoles can be transformed into the corresponding 1,5- and 2,5-disubstituted tetrazoles. 2,4′-Dibromoacetophenone gave the corresponding 2,5-disubstituted derivative as the only isomer. Synthesis of tetrazole derivatives with excellent yields in short times, a wide range of products under ultrasound irradiation, environmental benignity and a simple work-up procedure are some of the important features of this protocol.
ISSN:0932-0776
1865-7117
DOI:10.1515/znb-2015-0070