A Systematic Review of Community-Based Participatory Research to Enhance Clinical Trials in Racial and Ethnic Minority Groups

• Published in: Health services research Vol. 47; no. 3pt2; pp. 1363 - 1386
• Main Authors: De Las Nueces, Denise, Hacker, Karen, DiGirolamo, Ann, Hicks, LeRoi S.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.06.2012; Health Research and Educational Trust; Blackwell Science Inc
• Subjects: Cancer; Cancer screening; Care and treatment; Clinical trials; Clinical Trials as Topic - methods; Colorectal cancer; Community based action research; Community participation; Community-based participatory research; Community-Based Participatory Research - organization & administration; Diagnosis; Ethnic minorities; Ethnicity; Health Behavior; Humans; Intervention; Medical research; Minority & ethnic groups; Outcome and Process Assessment, Health Care; Participatory research; racial and ethnic minorities; Racial differences; Racial Groups; Recruitment; Research Design; Scholarly publishing; Special Issue: Measuring and Analyzing Health Care Disparities; Studies; systematic review; United States; United States > US
• ISSN: 0017-9124; 1475-6773; 1475-6773
• DOI: 10.1111/j.1475-6773.2012.01386.x

Objective To examine the effectiveness of current community‐based participatory research (CBPR) clinical trials involving racial and ethnic minorities. Data Source All published peer‐reviewed CBPR intervention articles in PubMed and CINAHL databases from January 2003 to May 2010. Study Design We performed a systematic literature review. Data Collection/Extraction Methods Data were extracted on each study's characteristics, community involvement in research, subject recruitment and retention, and intervention effects. Principle Findings We found 19 articles meeting inclusion criteria. Of these, 14 were published from 2007 to 2010. Articles described some measures of community participation in research with great variability. Although CBPR trials examined a wide range of behavioral and clinical outcomes, such trials had very high success rates in recruiting and retaining minority participants and achieving significant intervention effects. Conclusions Significant publication gaps remain between CBPR and other interventional research methods. CBPR may be effective in increasing participation of racial and ethnic minority subjects in research and may be a powerful tool in testing the generalizability of effective interventions among these populations. CBPR holds promise as an approach that may contribute greatly to the study of health care delivery to disadvantaged populations.