Clinical and experimental studies of coronary heart disease treated with yi-qi huo-xue injection

• Published in: Journal of traditional Chinese medicine Vol. 9; no. 3; p. 193
• Main Authors: Liao, J Z, Chen, J J, Wu, Z M, Guo, W Q, Zhao, L Y, Qin, L M, Wang, S R, Zhao, Y R
• Format: Journal Article
• Language: English
• Published: China 01.09.1989
• Subjects: Blood Viscosity - drug effects; Coronary Disease - blood; Coronary Disease - drug therapy; Drugs, Chinese Herbal - therapeutic use; Female; Heart - physiopathology; Humans; Injections, Intravenous; Male; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors
• ISSN: 0255-2922

The purpose of the present work was to evaluate the clinical efficacy and the mechanism of Yi-qi Huo-xue Injection (YHI) in treatment of coronary heart disease. YHI consists of Ginseng, Astragalus and Angelicae Sinensis. The 10% dextrose serves as a placebo. The results were as follows: 1. the frequency and severity of angina episodes were reduced by 90.63%; 2. the ischemic ST-T in ECG was improved in 56.25% of cases; 3. the tolerance to treadmill exercise was increased from 348.50 to 503.50 M.; 4. the left ventricular function was strengthened, PEP/LVET ratio reduced from 0.45 to 0.36, the activity of (Na(+)-K+) ATPase in myocardial cell membrane of rats inhibited by 19.2%; 5. the blood viscosity and erythrocyte electrophoretic time lowered; 6. the adhesion and aggregation of platelet in patients with CHD were inhibited by 27% and 59.4% respectively; 7. the plasma TXB2 level in CHD was reduced from 260.28 +/- 164.4 to 139.29 +/- 57.01 pg/ml; 8. the plasma 6-keto-PGF1 alpha level in CHD was increased from 33.45 +/- 22.5 to 57.48 +/- 13.1 pg/ml, and in rats from 185.77 to 366.33 pg/ml. The differences were all statistically significant (P less than 0.05-0.01) in comparison with the placebo group.