nticoagulative Effect of Two Species of Brown Algae; Sargassum Angustifolium and Cystoseira Indica

Background: Fucoidans are a group of sulfated fucose-rich polysaccharides that are isolated from brown marine algae and echinoderms, and recently have been found in seagrasses. Fucoidans, as well as their derivatives, have several beneficial biological effects and therapeutic potentials. In the pres...

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Published inResearch in molecular medicine Vol. 8; no. 3; pp. 125 - 132
Main Authors Obeidi, Narges, Mousavi, Mohammad Javad, Hosseinpouri, Arghavan, Malekhayati, Hamideh, Ehsandoost, Elham
Format Journal Article
LanguageEnglish
Published 01.07.2020
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Summary:Background: Fucoidans are a group of sulfated fucose-rich polysaccharides that are isolated from brown marine algae and echinoderms, and recently have been found in seagrasses. Fucoidans, as well as their derivatives, have several beneficial biological effects and therapeutic potentials. In the present study, we aimed to evaluate the anticoagulative effects of two species of brown algae, namely Sargassum angustifolium (S. angustifolium) and Cystoseira indica (C. indica). Methods: Fucoidan C and fucoidan S were extracted by an ethanol/water solvent system from S. angustifolium and C. indicia, respectively. The anticoagulative effects of fucoidan C and fucoidan S were tested on 10 normal serum samples by evaluating the rate of thrombin time (PT) and prothrombin time (PTT). Results: Both fucoidan C and fucoidan S significantly increased PTT. However, no significant difference was observed in PT. Fucoidan C had a greater effect on PTT prolongation compared with fucoidan S. Conclusion: Both fucoidans extracted from S. angustifolium and C. indicia can be used as anticoagulants in biotechnology and human disorders.
ISSN:2322-133X
2322-133X
DOI:10.32598/rmm.8.3.1099.3