Effect of antioxidants on thyroid hormones and reproductive status of animals depending on age

• Published in: Vìsnik medičnih ì bìologìčnih doslìdženʹ pp. 51 - 59
• Main Author: Stewart, Angelina
• Format: Journal Article
• Language: English
• Published: 21.12.2024
• ISSN: 2706-6282; 2706-6290
• DOI: 10.63341/bmbr/1.2025.51

The purpose of this study was to evaluate the effect of natural antioxidants on thyroid function, which may later affect their reproduction and pregnancy. 20 sexually mature rats were selected, which were divided into groups, and oxidative stress was modelled by the introduction of lipopolysaccharide Pyrogenal Salmonella typhi dissolved in saline, the results were determined on days 3, 5, 7, and 10 of pregnancy. It was found that the introduction of various substances determined the degree of influence of various antioxidants on the state of fertility of female and male rats of the Wistar line with the calculation of the level of hormonal background of the thyroid gland of subjects and the enzyme activity of antioxidant protection systems. As a result of the study, it was found that Wistar rats that consumed the antioxidants ubiquinone and lycopene experienced the least changes in reproductive functions and the preservation of offspring. It was also found that oxidative stress modelled on pregnant rats resulted in a significant 40% reduction in enzyme activity, and thyroid hormones were reduced by 90%. This study also delved into a new relatively unexplored theory of antioxidant fertility along with the hormonal background of the thyroid gland under conditions of oxidative stress, neurohumoral regulation, and prooxidant-oxidant balance under conditions of fertility have also been perfectly determined, this balance is provided by a number of antioxidant substances that are either already present in the body or obtained with food (for example, vitamins C and E)