Role of salivary MMP-9 in OSCC detection and diagnosis: A comprehensive clinical assessment
An Enzyme-Linked Immunosorbent Assay (ELISA) to measure the salivary Matrix metalloproteinase-9 (MMP-9) levels among squamous cell carcinoma patients was used. Thirty of the sixty participants in the research had a verified diagnosis of oral SCC, whereas the remaining twenty were healthy controls. S...
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| Published in | Bioinformation Vol. 21; no. 6; pp. 1680 - 1682 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
30.06.2025
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| Online Access | Get full text |
| ISSN | 0973-8894 0973-2063 |
| DOI | 10.6026/973206300211680 |
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| Abstract | An Enzyme-Linked Immunosorbent Assay (ELISA) to measure the salivary Matrix metalloproteinase-9 (MMP-9) levels among squamous cell carcinoma patients was used. Thirty of the sixty participants in the research had a verified diagnosis of oral SCC, whereas the remaining twenty were healthy controls. Salivary MMP-9 levels were extracted by centrifugation and measured using ELISA. The results were compared between oral SCC patients and controls. Participants with oral squamous cell carcinoma had considerably greater mean salivary MMP-9 levels than healthy subjects (p<0.05). Thus, individuals with oral squamous cell carcinoma have average salivary MMP-9 levels, and those with poorly differentiated oral squamous cell carcinoma have even higher levels. |
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| AbstractList | An Enzyme-Linked Immunosorbent Assay (ELISA) to measure the salivary Matrix metalloproteinase-9 (MMP-9) levels among squamous cell carcinoma patients was used. Thirty of the sixty participants in the research had a verified diagnosis of oral SCC, whereas the remaining twenty were healthy controls. Salivary MMP-9 levels were extracted by centrifugation and measured using ELISA. The results were compared between oral SCC patients and controls. Participants with oral squamous cell carcinoma had considerably greater mean salivary MMP-9 levels than healthy subjects (p<0.05). Thus, individuals with oral squamous cell carcinoma have average salivary MMP-9 levels, and those with poorly differentiated oral squamous cell carcinoma have even higher levels. |
| Author | Singh, Vijayta Agarwal, Parul Tomar, Indu Manek, Pranav Sisodia, Gajendra Singh Abraham, Dax |
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| CorporateAuthor | Department of Oral Medicine and Radiology, Pacific Dental College and Research Centre, Udaipur, Rajasthan, India Department of Oral Medicine and Dental Radiology, K D Dental College and hospital, Mathura, Uttar Pradesh, India Department of Conservative Dentistry and Endodontics, Manav Rachna Dental College, School of Dental Sciences, Manav Rachna International Institute of Research And Studies, Faridabad, Haryana, India Department of Pathology, Maharaja Suhel Dev Autonomous State Medical College & Mahrishi Balark Hospitals, Bahraich, Uttar Pradesh, India Department of Community Medicine, Pacific Medical College & Hospital, Udaipur, Rajasthan, India Department of Biochemistry, Research Scholar (PhD), Department of Biosciences, Manipal University, Jaipur, Rajasthan, India |
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