Role of salivary MMP-9 in OSCC detection and diagnosis: A comprehensive clinical assessment

An Enzyme-Linked Immunosorbent Assay (ELISA) to measure the salivary Matrix metalloproteinase-9 (MMP-9) levels among squamous cell carcinoma patients was used. Thirty of the sixty participants in the research had a verified diagnosis of oral SCC, whereas the remaining twenty were healthy controls. S...

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Bibliographic Details
Published inBioinformation Vol. 21; no. 6; pp. 1680 - 1682
Main Authors Manek, Pranav, Singh, Vijayta, Sisodia, Gajendra Singh, Tomar, Indu, Abraham, Dax, Agarwal, Parul
Format Journal Article
LanguageEnglish
Published 30.06.2025
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Summary:An Enzyme-Linked Immunosorbent Assay (ELISA) to measure the salivary Matrix metalloproteinase-9 (MMP-9) levels among squamous cell carcinoma patients was used. Thirty of the sixty participants in the research had a verified diagnosis of oral SCC, whereas the remaining twenty were healthy controls. Salivary MMP-9 levels were extracted by centrifugation and measured using ELISA. The results were compared between oral SCC patients and controls. Participants with oral squamous cell carcinoma had considerably greater mean salivary MMP-9 levels than healthy subjects (p<0.05). Thus, individuals with oral squamous cell carcinoma have average salivary MMP-9 levels, and those with poorly differentiated oral squamous cell carcinoma have even higher levels.
ISSN:0973-8894
0973-2063
DOI:10.6026/973206300211680