Composition of statins produced by indigenous strain of Aspergillus terreus
Composition of statins produced by Aspergillus terreus 20 indigenous strain in submerged fermentation (SmF) has been studied. Identification of statin compounds in fungal extracts by LC-MS-MS analysis revealed 6 polyketide metabolites: lovastatin (LV) in lactone, acid and methyl ester forms, pravast...
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Published in | International journal of engineering, science and technology Vol. 6; no. 1; pp. 71 - 76 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
08.02.2014
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Online Access | Get full text |
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Summary: | Composition of statins produced by Aspergillus terreus 20 indigenous strain in submerged fermentation (SmF) has been studied. Identification of statin compounds in fungal extracts by LC-MS-MS analysis revealed 6 polyketide metabolites: lovastatin (LV) in lactone, acid and methyl ester forms, pravastatin (PV), monacolin L (ML) and simvastatin (SV). For the first time it has been revealed the ability producing simvastatin by A. terreus by direct fermentation.Keywords: Aspergillus terreus, statins, composition, HPLC, LC-MS-MS analysis, mass spectraInternational Journal of Engineering, Science and Technology Vol. 6, No. 1, 2014, pp. 71-76 |
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ISSN: | 2141-2820 2141-2839 |
DOI: | 10.4314/ijest.v6i1.8 |