Noninferiority of 99m Tc-Ethylenedicysteine-Glucosamine as an Alternative Analogue to 18 F-Fluorodeoxyglucose in the Detection and Staging of Non-Small Cell Lung Cancer
Objective. 99 m Tc-ethylenedicysteine-glucosamine ( 99 m Tc-EC-G) was developed as a potential alternative to 18 F-FDG for cancer imaging. A Phase 2 study was conducted to compare 18 F-FDG PET/CT and 99 m Tc-EC-G SPECT/CT in the detection and staging of patients with non-small cell lung cancer (NSCL...
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Published in | Contrast media and molecular imaging Vol. 2018; pp. 1 - 9 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
2018
|
Online Access | Get full text |
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Summary: | Objective.
99
m
Tc-ethylenedicysteine-glucosamine (
99
m
Tc-EC-G) was developed as a potential alternative to
18
F-FDG for cancer imaging. A Phase 2 study was conducted to compare
18
F-FDG PET/CT and
99
m
Tc-EC-G SPECT/CT in the detection and staging of patients with non-small cell lung cancer (NSCLC). This study was aimed to demonstrate that
99
m
Tc-EC-G SPECT/CT was not inferior to
18
F-FDG PET/CT in patients with confirmed NSCLC.
Methods.
Seventeen patients with biopsy proven NSCLC were imaged with
99
m
Tc-EC-G and
18
F-FDG to detect and stage their cancers. Imaging with PET/CT began 45–60 minutes after injection of
18
F-FDG. Imaging with
99
m
Tc-EC-G began at two hours after injection (for 5 patients) or three hours (for 12 patients). SPECT/CT imaging devices from the three major vendors of SPECT/CT systems were used at 6 participating study sites. The image sets were blinded to all clinical information and interpreted by independent PET and SPECT expert readers at a central independent core laboratory.
Results.
100% concordance between
99
m
Tc-EC-G and
18
F-FDG for primary lesion detection, lesion location and size, and confidence that the biopsied lesion was malignant. There was 70% agreement between
99
m
Tc-EC-G and
18
F-FDG for metastatic lesion detection, location and size, and confidence that the suspicious lesions were malignant.
Conclusions.
Evaluation of primary and suspicious metastatic lesions detected by
99
m
Tc-EC-G and
18
F-FDG on 17 patients resulted in excellent agreement for detection of primary and metastatic lesions. The study results indicated that
99
m
Tc-EC-G SPECT/CT has the potential to be a clinically viable alternative to
18
F-FDG PET/CT and
99
m
Tc-EC-G is not inferior to
18
F-FDG PET/CT. |
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ISSN: | 1555-4309 1555-4317 |
DOI: | 10.1155/2018/8969714 |