Dependence of 18 F Production Yield and Radioactive Impurities on Proton Irradiation Dose

• Published in: Physics research international Vol. 2017; pp. 1 - 5
• Main Authors: Kambali, Imam, Parwanto, Suryanto, Hari, Huda, Nur, Listiawadi, Ferdi D., Astarina, Herta, Ismuha, Ratu R., Kardinah
• Format: Journal Article
• Language: English
• Published: 09.10.2017
• ISSN: 2090-2220; 2090-2239
• DOI: 10.1155/2017/2124383

Radiation safety for patients during positron emission tomography (PET) procedures is affected by the amount of radioactive impurities generated during production of fluorine-18 ( 18 F) radionuclide. In this investigation, the dependence of 18 F production yield and radioactive impurities on proton irradiation dose is discussed. Enriched water ( H 2 O 18 ) target was bombarded perpendicularly by 11-MeV proton beams at various proton doses. Experimental results indicated that the 18 F radioactivity yield and the amount of 56 Co and A g 110 m radioactive impurities depend strongly on the proton dose. In the proton dose range between 2  μ Ahr and 20  μ Ahr, the radioactive impurities increased with increasing proton dose. There was no significant difference in the radioactivity yield of both 56 Co and A g 110 m impurities at low proton dose between 2 and 10  μ Ahr. However a huge difference was recorded when the dose was increased above 10  μ Ahr. The experimental data can be used to predict the amount of impurities generated during 18 F production at proton dose of higher than 20  μ Ahr.