Preparation of a Novel Thiol Surface Modifier and Fe 3 O 4 Drug Loading Agent as well as Releasing under pH-Sensitivity

• Published in: Journal of nanomaterials Vol. 2020; pp. 1 - 14
• Main Authors: Ya-zhen, Wang, Xue-ying, Wu, Yu-tao, Di, Tian-yu, Lan, Li-wu, Zu
• Format: Journal Article
• Language: English
• Published: 08.05.2020
• ISSN: 1687-4110; 1687-4129
• DOI: 10.1155/2020/5492953

In this paper, in order to take advantage of the combination between magnetic nano-Fe 3 O 4 and surface modifier, a pH-sensitive drug delivery system that could effectively deliver doxorubicin (DOX) to tumor tissue was constructed. The novel drug delivery system named Fe 3 O 4 -TIPTS-g-(PEI-co-PEG) was prepared through three steps. The first step, a surface modifier with the thiol group, thiohydrazide-iminopropyltriethoxysilane surface modifier (named TIPTS), was synthesized for the first time. The second step, Fe 3 O 4 -TIPTS was synthesized by treating nano-Fe 3 O 4 with TIPTS. The last step, Fe 3 O 4 -TIPTS-g-(PEI-co-PEG) was synthesized in the presence of the Fe 3 O 4 -TIPTS, polyethyleneimine (PEI), and polyethylene glycol (PEG) by mercapto-initiated radical polymerization. Among them, magnetic nanoparticles (MNPs) were used as magnetically responsive carriers, PEG was the surface-modifying compound, and PEI was the drug loading site which primary amine reacts with doxorubicin (DOX). Targeted nanoparticles were considerably stabilize in various physiological solutions and exhibited pH-sensitive performance in drug release. Thence, Fe 3 O 4 -TIPTS-g-(PEI-co-PEG) is a promising nanocarrier for targeting tumor therapy.