The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

• Published in: Nature (London) Vol. 574; no. 7777; pp. 187 - 192
• Main Authors: Snyder, Michael P, Lin, Shin, Posgai, Amanda, Atkinson, Mark, Regev, Aviv, Rood, Jennifer, Rozenblatt-Rosen, Orit
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2019; Nature Publishing Group
• Subjects: 38/39; 45; 45/23; 45/91; 631/114/2398; 631/208/212; 82/80; Accessibility; Aging; Analysis; Atlases as Topic; BASIC BIOLOGICAL SCIENCES; Biomedical Research - organization & administration; Body, Human; Brain research; Chromosome mapping; Collaboration; Consortia; Data acquisition; Diabetes; Female; Gene expression; Health; Human body; Humanities and Social Sciences; Humans; Identification and classification; International Cooperation; Localization; Male; Mapping; Models, Anatomic; Molecular Biology - organization & administration; multidisciplinary; National Institutes of Health (U.S.) - organization & administration; Organ Specificity; Perspective; Proteins; Science; Science (multidisciplinary); Service development; Single-Cell Analysis; Spatial data; Technology application; Tissues; United States; United States
• ISSN: 0028-0836; 1476-4687; 1476-4687
• DOI: 10.1038/s41586-019-1629-x

Transformative technologies are enabling the construction of three-dimensional maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution by supporting technology development, data acquisition, and detailed spatial mapping. HuBMAP will integrate its efforts with other funding agencies, programs, consortia, and the biomedical research community at large towards the shared vision of a comprehensive, accessible three-dimensional molecular and cellular atlas of the human body, in health and under various disease conditions. HuBMAP supports technology development, data acquisition, and spatial analyses to generate comprehensive molecular and cellular three-dimensional tissue maps.