No Major Schizophrenia Locus Detected on Chromosome 1q in a Large Multicenter Sample

• Published in: Science (American Association for the Advancement of Science) Vol. 296; no. 5568; pp. 739 - 741
• Main Authors: Levinson, Douglas F., Holmans, Peter A., Laurent, Claudine, Riley, Brien, Pulver, Ann E., Gejman, Pablo V., Schwab, Sibylle G., Williams, Nigel M., Owen, Michael J., Wildenauer, Dieter B., Sanders, Alan R., Nestadt, Gerald, Mowry, Bryan J., Wormley, Brandon, Bauché, Stéphanie, Soubigou, Stéphane, Ribble, Robert, Nertney, Deborah A., Liang, Kung Yee, Martinolich, Laura, Maier, Wolfgang, Norton, Nadine, Williams, Hywel, Albus, Margot, Carpenter, Eric B., deMarchi, Nicola, Ewen-White, Kelly R., Walsh, Dermot, Jay, Maurice, Deleuze, Jean-François, O'Neill, F. Anthony, Papadimitriou, George, Weilbaecher, Ann, Lerer, Bernard, O'Donovan, Michael C., Dikeos, Dimitris, Silverman, Jeremy M., Kendler, Kenneth S., Mallet, Jacques, Crowe, Raymond R., Walters, Marilyn
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 26.04.2002; American Association for the Advancement of Science; The American Association for the Advancement of Science; American Association for the Advancement of Science (AAAS)
• Subjects: Adult and adolescent clinical studies; Africa; Alleles; Australia; Biological and medical sciences; Canada; Cellular Biology; Chromosome 1; Chromosomes; Chromosomes, Human, Pair 1 - genetics; Datasets; Ethnicity; Europe; Evidence; Female; Genes; Genes, Recessive; Genetic aspects; Genetic Linkage; Genetic loci; Genetic Predisposition to Disease; Genetics; Genotype; Grants; Human chromosome abnormalities; Humans; Intelligence Quotient; Life Sciences; Lod Score; Male; Medical genetics; Medical research; Medical sciences; Microsatellite Repeats; Modeling; Pedigree; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - ethnology; Schizophrenia - genetics; Statistical analysis; Subcellular Processes; United States; Canada; Australia; United States; Europe; Africa; Psychosis; Human; Linkage; Gene; Schizophrenia; Genetic determinism; Chromosome 1
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.1069914

Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.