European H16N3 gull influenza virus attaches to the human respiratory tract and eye

We explored the attachment of an H16N3 influenza virus to human, mallard, and gull tissues using virus histochemistry applied to tissue microarrays and employing human and mallard viruses as references. Of the viruses tested, the H16N3 gull virus most readily attached to the human respiratory tract...

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Published inPloS one Vol. 8; no. 4; p. e60757
Main Authors Lindskog, Cecilia, Ellström, Patrik, Olsen, Björn, Pontén, Fredrik, van Riel, Debby, Munster, Vincent J, González-Acuña, Daniel, Kuiken, Thijs, Jourdain, Elsa
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 08.04.2013
Public Library of Science (PLoS)
Subjects
Anas platyrhynchos
Animals
Biologi med inriktning mot mikrobiologi
Biology with specialization in Microbiology
Charadriiformes
Charadriiformes - virology
Dogs
Ecological effects
Ecological monitoring
Ecology
Europe
Eye
Eye - virology
Gulls
Histochemistry
Histology
Human tissues
Humans
Immunology
Infectious diseases
Influenza
Influenza A virus
Influenza A virus - physiology
Influenza viruses
Laboratories
Laridae
Life Sciences
Madin Darby Canine Kidney Cells
Mammals
Medicine
Pandemics
Pathology
Proteins
Proteomics
Respiratory System
Respiratory System - virology
Respiratory tract
Studies
Tissues
Veterinary Science
Virology
Virus Attachment
Viruses
Wildfowl
Zoonoses
Europe
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Summary:We explored the attachment of an H16N3 influenza virus to human, mallard, and gull tissues using virus histochemistry applied to tissue microarrays and employing human and mallard viruses as references. Of the viruses tested, the H16N3 gull virus most readily attached to the human respiratory tract and eye. These results underscore the need to assess the potential for gull influenza viruses to replicate in human tissues and further investigate the role of gulls in influenza virus ecology.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Competing Interests: The authors have declared that no competing interests exist.
Obtained permissions for tissue sampling: FP PE BO DGA. Conceived and designed the experiments: EJ PE BO. Performed the experiments: CL EJ. Analyzed the data: CL EJ PE DvR. Contributed reagents/materials/analysis tools: FP PE BO VM TK DGA. Wrote the paper: EJ CL PE DvR VM TK.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0060757