Evaluating the Effect of Childhood Obesity on Choroidal Structures
Aim: To evaluate the effect of childhood obesity on choroidal structures with spectral-domain optical coherence tomography (SD-OCT). Material and Methods: A total of 80 children (20 children per each group; healthy, overweight, obese, and morbid-obese) were included in the study. Accompanying comorb...
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Published in | Turkish Journal of Diabetes and Obesity Vol. 8; no. 1; pp. 6 - 12 |
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Main Authors | , , , , |
Format | Journal Article |
Language | Turkish |
Published |
29.04.2024
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Online Access | Get full text |
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Summary: | Aim: To evaluate the effect of childhood obesity on choroidal structures with spectral-domain optical coherence tomography (SD-OCT).
Material and Methods: A total of 80 children (20 children per each group; healthy, overweight, obese, and morbid-obese) were included
in the study. Accompanying comorbidities such as insulin resistance, dyslipidemia, and metabolic syndrome were recorded. The
subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) measurements were obtained from SD-OCT images and
compared between groups.
Results: No notable differences were found between groups regarding the means of age and axial length (p=0.504, and p=0.805,
respectively). The SFCT medians (min-max) of healthy, overweight, obese, and morbid-obese children were 398.5 (319.0-453.5) μm,
299.0 (274.7-387.0) μm, 295.5 (257.0-385.0) μm, and 304.5 (272.2-386.0) μm respectively. Overweight and obese children had thinner
choroid than non-obese healthy children (p=0.032). Besides, no significant correlation was observed between the severity of obesity and
SFCT (p=0.722). In terms of CVI, total choroidal area, luminal area, and stromal area; no significant differences were found between
groups (p=0.710, p=0.452, p=0.221, and p=0.863, respectively). Obese children with dyslipidemia had thinner SFCT than those not have
dyslipidemia (292.0 (166-431)μm vs 348.0(173-491)μm, p=0.003), while insulin resistance and metabolic syndrome had no effect on
SFCT (p=0.336, and p=0.211, respectively).
Conclusion: Childhood obesity and accompanying dyslipidemia led to a decrease in SFCT without any significant change in the CVI.
However, the severity of obesity and having insulin resistance or metabolic syndrome had no effect on either SFCT or CVI. The thinning
in the SFCT may be related to microvascular disorders due to childhood obesity and dyslipidemia |
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ISSN: | 2587-0335 |
DOI: | 10.25048/tudod.1400388 |