Application of Ancestry Informative Markers to Association Studies in European Americans

[...]depending on the number of case and control samples and the cost of prescreening with AIM panels, it may be advantageous to first match cases and controls for ancestry. [...]if a variant is more polymorphic or has higher relative risk in samples of a particular ancestry, then a more genetically...

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Bibliographic Details
Published inPLoS genetics Vol. 4; no. 1; p. e5
Main Authors Seldin, Michael F., Price, Alkes L.
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 2008
Public Library of Science (PLoS)
Subjects
Alleles
Associations
Chromosomes, Human
European Continental Ancestry Group - genetics
Gene Frequency
Genealogy
Genetic Markers
Genetics
Genetics and Genomics
Genetics, Population
Geography
Health risk assessment
Humans
Ireland - ethnology
Jews - ethnology
Methods
Oligonucleotide Array Sequence Analysis
Physical Chromosome Mapping
Population
Principal components analysis
Studies
United States
United States
Ireland
Europe
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Summary:[...]depending on the number of case and control samples and the cost of prescreening with AIM panels, it may be advantageous to first match cases and controls for ancestry. [...]if a variant is more polymorphic or has higher relative risk in samples of a particular ancestry, then a more genetically homogeneous group of subjects (for example, focusing on Ashkenazi Jewish ancestry [14]) may be more likely to reveal that variant.
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ISSN:1553-7390
1553-7404
1553-7404
DOI:10.1371/journal.pgen.0040005