Inside Cover

Abstract Biological cells are highly light scattering, largely precluding the optical access of light microscopes into living tissues. Using a scheme of mutation and high throughput optical selection, the authors present the directed evolution of mammalian cells towards increased transparency. The e...

Full description

Saved in:
Bibliographic Details
Published inJournal of biophotonics Vol. 14; no. 4
Main Authors Subramanian, Kaushikaram, Petzold, Heike, Seelbinder, Benjamin, Hersemann, Lena, Nüsslein, Ina, Kreysing, Moritz
Format Journal Article
LanguageEnglish
Published 01.04.2021
Online AccessGet full text

Cover

More Information
Summary:Abstract Biological cells are highly light scattering, largely precluding the optical access of light microscopes into living tissues. Using a scheme of mutation and high throughput optical selection, the authors present the directed evolution of mammalian cells towards increased transparency. The evolved cells replicate and reflect a physiological state, while showing strongly reduced light scattering, which motivates the authors to propose the generation of genetically enhanced, optically superior tissues (GHOSTs) to advance life microscopy. Further details can be found in the article by Kaushikaram Subramanian, Heike Petzold, Benjamin Seelbinder, LenaHersemann, Ina Nüsslein, and Moritz Kreysing. ( e202000457 ). image
ISSN:1864-063X
1864-0648
DOI:10.1002/jbio.202170013