Rapid diagnosis of periodontitis, a feasibility study using MALDI-TOF mass spectrometry

• Published in: PloS one Vol. 15; no. 3; p. e0230334
• Main Authors: Antezack, Angéline, Chaudet, Hervé, Tissot-Dupont, Hervé, Brouqui, Philippe, Monnet-Corti, Virginie
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.03.2020; Public Library of Science (PLoS)
• Subjects: Bacteriology; Biology and Life Sciences; Biomarkers; Cardiology and cardiovascular system; Criminal investigation; Decision trees; Dental materials; Dental plaque; Diagnosis; Diagnostic systems; Disease; Emerging diseases; Engineering and Technology; Feasibility studies; Gum disease; Health care; Human health and pathology; Infections; Infectious diseases; Life Sciences; Mass spectrometry; Mass spectroscopy; Medical diagnosis; Medical tests; Medicine and Health Sciences; Microbiology and Parasitology; Odontology; Parasitology; Patients; Periodontics; Periodontitis; Periodontium; Physical Sciences; Proteins; Research and Analysis Methods; Saliva; Scientific imaging; Sensitivity; Spectroscopy; Teeth; Time; Virology; France; Periodontal diseases; Periodontitis; Diagnostic medicine; Teeth; Matrix-assisted laser desorption ionization time-of-flight mass spectrometry; Decision trees; Saliva; Epidemiology

The aim of the present study was to assess the feasibility and diagnostic contribution of protein profiling using MALDI-TOF mass spectrometry applied to saliva, gingival crevicular fluid (GCF) and dental plaque from periodontitis and healthy subjects. We hypothesized that rapid routine and blinded M...