Effect of the Chronic Use of Lithium Carbonate on Induced Tooth Movement in Wistar Rats

• Published in: PloS one Vol. 11; no. 8; p. e0160400
• Main Authors: da Silva Kagy, Viviane, Trevisan Bittencourt Muniz, Luciana, Michels, Arieli Carini, Luiz, Suelen Teixeira, Reis Azevedo Alanis, Luciana, Brancher, João Armando, Grégio, Ana Maria Trindade, Ignácio, Sérgio Aparecido, Camargo, Elisa Souza, Machado, Maria Ângela Naval, Johann, Aline Cristina Batista Rodrigues
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.08.2016; Public Library of Science (PLoS)
• Subjects: Alkaline phosphatase; Animals; Antimanic Agents - administration & dosage; Antimanic Agents - adverse effects; Antipsychotic agents; Biocompatibility; Biology and Life Sciences; Biomedical materials; Bipolar disorder; Bone Remodeling - drug effects; Carbonates; Creatinine; Drug Administration Schedule; Drug dosages; Lithium; Lithium carbonate; Lithium Carbonate - administration & dosage; Lithium Carbonate - adverse effects; Male; Medicine and Health Sciences; Orthodontic Appliances; Orthodontics; Osteoclasts; Phosphatases; Phosphates; Physical Sciences; Rats; Rats, Wistar; Reduction; Rodents; Systematic review; Teeth; Time Factors; Tooth - drug effects; Tooth - physiology; Tooth Mobility - pathology; Tooth Movement Techniques; Brazil
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0160400

Patients who seek dental treatment may have bipolar disorder, and lithium carbonate (LC) is the drug of choice used in the treatment of this disorder. Taking into consideration the controversial results found in the literature, and the possible influence of LC on induced tooth movement, the objective was to evaluate tooth movement induced in rats after administration of lithium carbonate. One hundred and ninety-two rats were divided into 3 groups. In the L group, the animals received daily 60mg/kg of LC, they were not subjected to orthodontic movement, and they were euthanized after 33, 37, 44 or 51 days. In the LM group, the LC was administered for 30 days and during the subsequent 3, 7, 14 and 21 days, corresponding to the period of induced tooth movement, and they received a spring that produced a 30cN force. In the SM group, saline solution was applied. Measurements were made of tooth displacement, the numbers of osteoclasts and serum lithium phosphate (PO4), alkaline phosphatase (ALP) and creatinine levels. The tooth displacement was lower in the LM group compared to the SM group at 44 days. A tendency toward reduction in the number of osteoclasts was observed in the LM group compared to the SM group at 44 days. The average lithium were higher in the L and LM groups compared to the SM group. The opposite was observed for the PO4 group. A higher value for the ALP was found in the L group. The average creatinine level was lower in the LM group. LC inhibited tooth movement for 14 days, possibly due to the reduction in the number of osteoclasts.