Diffusion-Weighted MRI Reflects Proliferative Activity in Primary CNS Lymphoma

• Published in: PloS one Vol. 11; no. 8; p. e0161386
• Main Authors: Schob, Stefan, Meyer, Jonas, Gawlitza, Matthias, Frydrychowicz, Clara, Müller, Wolf, Preuss, Matthias, Bure, Lionel, Quäschling, Ulf, Hoffmann, Karl-Titus, Surov, Alexey
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.08.2016; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; Biology and Life Sciences; Biopsy; Brain cancer; Care and treatment; Cell cycle; Cell division; Central nervous system; Central Nervous System Neoplasms - diagnosis; Central Nervous System Neoplasms - metabolism; Correlation; Diagnosis; Diffusion; Diffusion coefficient; Diffusion Magnetic Resonance Imaging - methods; Female; Humans; Ki-67 Antigen - metabolism; Lymphoma; Lymphoma - diagnosis; Lymphoma - metabolism; Magnetic resonance; Magnetic resonance imaging; Male; Medicine and Health Sciences; Middle Aged; Nervous system; Nervous system cancer; Neuropathology; NMR; Nuclear magnetic resonance; Nuclei; Patients; Radiology; Research and Analysis Methods; Retrospective Studies; Statistical analysis; Statistical methods; Statistical significance; Tumors; Germany
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0161386

To investigate if apparent diffusion coefficient (ADC) values within primary central nervous system lymphoma correlate with cellularity and proliferative activity in corresponding histological samples. Echo-planar diffusion-weighted magnetic resonance images obtained from 21 patients with primary central nervous system lymphoma were reviewed retrospectively. Regions of interest were drawn on ADC maps corresponding to the contrast enhancing parts of the tumors. Biopsies from all 21 patients were histologically analyzed. Nuclei count, total nuclei area and average nuclei area were measured. The proliferation index was estimated as Ki-67 positive nuclei divided by total number of nuclei. Correlations of ADC values and histopathologic parameters were determined statistically. Ki-67 staining revealed a statistically significant correlation with ADCmin (r = -0.454, p = 0.038), ADCmean (r = -0.546, p = 0.010) and ADCmax (r = -0.515, p = 0.017). Furthermore, ADCmean correlated in a statistically significant manner with total nucleic area (r = -0.500, p = 0.021). Low ADCmin, ADCmean and ADCmax values reflect a high proliferative activity of primary cental nervous system lymphoma. Low ADCmean values-in concordance with several previously published studies-indicate an increased cellularity within the tumor.