Altered Functional Connectivity and Small-World in Mesial Temporal Lobe Epilepsy

• Published in: PloS one Vol. 5; no. 1; p. e8525
• Main Authors: Liao, Wei, Zhang, Zhiqiang, Pan, Zhengyong, Mantini, Dante, Ding, Jurong, Duan, Xujun, Luo, Cheng, Lu, Guangming, Chen, Huafu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.01.2010; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Alterations; Alzheimer's disease; Alzheimers disease; Brain; Brain architecture; Brain mapping; Brain research; Case-Control Studies; Clustering; Computational Biology/Computational Neuroscience; Computational Biology/Signaling Networks; Correlation analysis; Cortex; Education; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe - physiopathology; Female; Functional magnetic resonance imaging; Humans; Hypotheses; Laboratories; Life sciences; Lobes; Magnetic resonance; Magnetic Resonance Imaging; Male; Medical imaging; Mental disorders; Middle Aged; Neural networks; Neuroimaging; Neurons; Neuroscience; Patients; Properties (attributes); Radiology and Medical Imaging/Magnetic Resonance Imaging; Studies; Temporal lobe; Temporal lobe epilepsy; Young Adult; Italy; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0008525

The functional architecture of the human brain has been extensively described in terms of functional connectivity networks, detected from the low-frequency coherent neuronal fluctuations that can be observed in a resting state condition. Little is known, so far, about the changes in functional connectivity and in the topological properties of functional networks, associated with different brain diseases. In this study, we investigated alterations related to mesial temporal lobe epilepsy (mTLE), using resting state functional magnetic resonance imaging on 18 mTLE patients and 27 healthy controls. Functional connectivity among 90 cortical and subcortical regions was measured by temporal correlation. The related values were analyzed to construct a set of undirected graphs. Compared to controls, mTLE patients showed significantly increased connectivity within the medial temporal lobes, but also significantly decreased connectivity within the frontal and parietal lobes, and between frontal and parietal lobes. Our findings demonstrated that a large number of areas in the default-mode network of mTLE patients showed a significantly decreased number of connections to other regions. Furthermore, we observed altered small-world properties in patients, along with smaller degree of connectivity, increased n-to-1 connectivity, smaller absolute clustering coefficients and shorter absolute path length. We suggest that the mTLE alterations observed in functional connectivity and topological properties may be used to define tentative disease markers.