Role of Intracellular Ca 2+ and Na + /Ca 2+ Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury

The precise mechanisms underlying contrast-induced acute kidney injury (CI-AKI) are not well understood. Intracellular Ca 2+ overload is considered to be a key factor in CI-AKI. Voltage-dependent Ca 2+ channel (VDC) and Na + /Ca 2+ exchanger (NCX) system are the main pathways of intracellular Ca 2+...

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Bibliographic Details
Published inBioMed research international Vol. 2013; pp. 1 - 5
Main Authors Yang, Dingping, Yang, Dingwei
Format Journal Article
LanguageEnglish
Published 2013
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Summary:The precise mechanisms underlying contrast-induced acute kidney injury (CI-AKI) are not well understood. Intracellular Ca 2+ overload is considered to be a key factor in CI-AKI. Voltage-dependent Ca 2+ channel (VDC) and Na + /Ca 2+ exchanger (NCX) system are the main pathways of intracellular Ca 2+ overload in pathological conditions. Here, we review the potential underlying mechanisms involved in CI-AKI and discuss the role of NCX-mediated intracellular Ca 2+ overload in the contrast media-induced renal tubular cell injury and renal hemodynamic disorder.
ISSN:2314-6133
2314-6141
DOI:10.1155/2013/678456