Synthesis and characterization of Bi 2 O 3 /HSA core‐shell nanoparticles for X‐ray imaging applications
Abstract Bismuth oxide nanoparticles of 12.1 ± 3.0 nm diameter were prepared by thermal decomposition of bismuth acetate dissolved in ethylene glycol in the presence of an oxidizing agent. Functionalization and stabilization of the hydrophobic Bi 2 O 3 nanoparticles was accomplished by coating these...
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Published in | Journal of biomedical materials research. Part B, Applied biomaterials Vol. 101B; no. 1; pp. 131 - 138 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
01.01.2013
|
Online Access | Get full text |
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Summary: | Abstract
Bismuth oxide nanoparticles of 12.1 ± 3.0 nm diameter were prepared by thermal decomposition of bismuth acetate dissolved in ethylene glycol in the presence of an oxidizing agent. Functionalization and stabilization of the hydrophobic Bi
2
O
3
nanoparticles was accomplished by coating these core nanoparticles with human serum albumin (HSA), via a precipitation process. The formed Bi
2
O
3
/HSA core‐shell nanoparticles were of 15.2 ± 3.5 nm diameter. Elemental analysis measurements indicated that the bismuth weight % of the Bi
2
O
3
/HSA core‐shell nanoparticles is 72.9. The crystalline structure of these nanoparticles was examined by XRD. The radiopacity of these nanoparticles was demonstrated
in vitro
and
in vivo
by a CT scanner.
In ovo
and
in vivo
trials proved the safety of these Bi
2
O
3
/HSA core‐shell nanoparticles. In the future, we plan to extend this study particularly for molecular imaging applications. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 131–138, 2013. |
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ISSN: | 1552-4973 1552-4981 |
DOI: | 10.1002/jbm.b.32826 |