Radical-mediated dehydrative preparation of cyclic imides using (NH 4 ) 2 S 2 O 8 –DMSO: application to the synthesis of vernakalant

Ammonium persulfate–dimethyl sulfoxide (APS–DMSO) has been developed as an efficient and new dehydrating reagent for a convenient one-pot process for the synthesis of miscellaneous cyclic imides in high yields starting from readily available primary amines and cyclic anhydrides. A plausible radical...

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Bibliographic Details
Published inBeilstein journal of organic chemistry Vol. 11; pp. 1008 - 1016
Main Authors Garad, Dnyaneshwar N, Tanpure, Subhash D, Mhaske, Santosh B
Format Journal Article
LanguageEnglish
Published 12.06.2015
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Summary:Ammonium persulfate–dimethyl sulfoxide (APS–DMSO) has been developed as an efficient and new dehydrating reagent for a convenient one-pot process for the synthesis of miscellaneous cyclic imides in high yields starting from readily available primary amines and cyclic anhydrides. A plausible radical mechanism involving DMSO has been proposed. The application of this facile one-pot imide forming process has been demonstrated for a practical synthesis of vernakalant.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.11.113