Prevalence and correlates of intestinal schistosomiasis infection among school-aged children in North-Western Tanzania

• Published in: PloS one Vol. 15; no. 2; p. e0228770
• Main Authors: Mnkugwe, Rajabu Hussein, Minzi, Omary S, Kinung'hi, Safari M, Kamuhabwa, Appolinary A, Aklillu, Eleni
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.02.2020; Public Library of Science (PLoS)
• Subjects: Adolescents; Analysis; Anemia; Anthropometry; Chemotherapy; Child; Children; Clinical trials; Coinfection - complications; Cross-Sectional Studies; Diagnostic systems; Disease; Diseases; Earth Sciences; Ecology and Environmental Sciences; Eggs; Elementary school students; Female; Health aspects; Hemoglobin; Hemoglobins; Humans; Infection; Infections; Intestinal Diseases, Parasitic - complications; Intestinal Diseases, Parasitic - epidemiology; Intestine; Laboratories; Low income groups; Luminous intensity; Malaria; Malaria - complications; Male; Male identity; Malnutrition - complications; Medical research; Medicin och hälsovetenskap; Medicine and Health Sciences; Morbidity; Mortality; Nutritional status; People and Places; Pharmacology; Pharmacy; Praziquantel; Prevalence; Public health; Rain; Regression analysis; Rural Population - statistics & numerical data; Schistosomiasis; Schistosomiasis - complications; Schistosomiasis - epidemiology; Social Sciences; Studies; Surveys; Tanzania - epidemiology; Tropical diseases; Vector-borne diseases; Tanzania; Kenya; Sub-Saharan Africa; Lake Victoria; Sweden
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0228770

Schistosomiasis is a neglected tropical disease that continues to cause morbidity and mortality in Sub Saharan Africa. Due to its endemicity, co-infection with malaria is common. The diseases cause anaemia and impaired nutritional status among children. We investigated the prevalence of intestinal schistosomiasis and its association with malaria, anaemia and nutritional status among school children. This was a cross sectional survey among 830 children in Nyamikoma village along Lake Victoria in Tanzania. A pre-tested questionnaire was used to collect socio-demographic data, history of drug use, and clinical data. Two faecal samples were collected on two consecutive days and analyzed using thick smears Kato Katz method. Diagnosis of malaria was done by malaria rapid diagnostic test, and haemoglobin concentration was determined using HemoCue. Nutritional status was assessed by anthropometric measurements. The overall prevalence of intestinal schistosomiasis was 90.6% (95% CI = 88.6% - 92.6%). Intensity of infection was light 24.1% (200/830), moderate 38.4% (319/830) and heavy 28.1% (233/830). Pre-adolescents (≤12 years) were more infected with intestinal schistosomiasis (93.2%) than adolescents (>12 years) (84.7%) (p < 0.001). Prevalence of malaria was 1.7% (14/824), and that of intestinal schistosomiasis-malaria co-infection was 1.6% (13/824). The overall prevalence of anaemia was 24.6% (95%CI = 18.7% - 30.5%). Severe anaemia was found in 2.3% (19/824) of study participants. The prevalence of stunting and wasting were 29.0% and 11.3%, respectively. On both univariate and multivariate regression analysis, only lower age was significantly associated intestinal schistosomiasis infection, but not anemia, malaria, stunting or wasting. However among those infected, a negative binomial regression analysis indicated independent significant association of male sex, loose stool consistency, and stunting with high eggs count/gram of stool. Despite several rounds of annual mass praziquantel administration, intestinal schistosomiasis is highly prevalent among school children particularly in younger children living in the study area. Biannual targeted mass praziquantel treatments or alternative regimens may be considered in future in the study area to redress the situation.