Mannose-binding lectin 2 polymorphisms do not influence frequency or type of infection in adults with chemotherapy induced neutropaenia

• Published in: PloS one Vol. 7; no. 2; p. e30819
• Main Authors: Wong, Michelle, Öhrmalm, Lars, Broliden, Kristina, Aust, Carl, Hibberd, Martin, Tolfvenstam, Thomas
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.02.2012; Public Library of Science (PLoS)
• Subjects: Adult; Adults; Anti-Bacterial Agents - therapeutic use; Antigens; Antineoplastic Agents - adverse effects; Bacteria; Binding; Biology; Blood clots; C-Reactive Protein - metabolism; Care and treatment; Chemotherapy; Cytokines; Deoxyribonucleic acid; Disease susceptibility; DNA; Fever; Fever - blood; Fever - complications; Fever - genetics; Fever - microbiology; Gene Frequency - genetics; Gene polymorphism; Genes; Genetic aspects; Genetic disorders; Genotype; Genotypes; Haplotypes; Hematology; Hospitals; Humans; Immune system; Infection; Infection - blood; Infection - epidemiology; Infection - genetics; Infection - microbiology; Infections; Infectious diseases; Influenza; Laboratories; Lectins; Mannose; Mannose-binding lectin; Mannose-Binding Lectin - blood; Mannose-Binding Lectin - genetics; Medical records; Medical research; Medical treatment; Medicin och hälsovetenskap; Medicine; Monosaccharides; Mutation; Neutropenia - chemically induced; Neutropenia - complications; Neutropenia - genetics; Neutropenia - microbiology; Patients; Plasma; Plasmas (physics); Polymorphism; Polymorphism, Single Nucleotide - genetics; Protein binding; Proteins; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Studies; Sweden - epidemiology; Transplants & implants; Virus diseases; Viruses; Sweden; Singapore
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0030819

Mannose-binding Lectin protein (MBL) has been suggested to be relevant in the defence against infections in immunosuppressed individuals. In a Swedish adult cohort immunosuppressed from both the underlying disease and from iatrogenic treatments for their underlying disease we investigated the role of MBL in susceptibility to infection. In this cross sectional, prospective study, blood samples obtained from 96 neutropaenic febrile episodes, representing 82 individuals were analysed for single nucleotide polymorphism (SNP) in the MBL2 gene. Concurrent measurement of plasma MBL protein concentrations was also performed for observation of acute response during febrile episodes. No association was observed between MBL2 genotype or plasma MBL concentrations, and the type or frequency of infection. Adding to the literature, we found no evidence that viral infections or co-infections with virus and bacteria would be predisposed by MBL deficiency. We further saw no correlation between MBL2 genotype and the risk of fever. However, fever duration in febrile neutropaenic episodes was negatively associated with MBL2 SNP mutations (p<0.05). Patients with MBL2 SNP mutations presented a median febrile duration of 1.8 days compared with 3 days amongst patients with wildtype MBL2 genotype. We found no clear association between infection, or infection type to MBL2 genotypes or plasma MBL concentration, and add to the reports casting doubts on the benefit of recombinant MBL replacement therapy use during iatrogenic neutropaenia.