Vitamin D deficiency and autoimmune thyroid diseases

• Published in: Experimental and Clinical Endocrinology & Diabetes
• Main Authors: Körber-Hafner, N, Körber, C
• Format: Conference Proceeding
• Language: English
• Published: 12.03.2015
• ISSN: 0947-7349; 1439-3646
• DOI: 10.1055/s-0035-1547749

Aim of Study: Vitamin D deficiency is considered to be a predictor for chronic diseases Here the correlation to thyroid autoimmune disorders should be evaluated. Method: In blood samples of 880 patients with autoimmune thyroid diseases we measured TSH-level (BRAHMS Hennigsdorf, TSH 1), parathyroid hormone levels (IBL, parathyroid hormone total intact IRMA) and 25-hydroxyvitamin-D (IBL, 25 OH-Vit D3-RIA CT). These data were correlated to gender, age, thyroid volume diagnosed by ultrasound (ESAOTE my lab seven), thyroid hormone, thyroid medication and the influence of these parameters according to the level of D3 was statistically analysed. Also TPO-levels (each BRAHMS, anti TPOn), TRAK (TRAK human) and fT4-levels (FT4 RIA) were correlated. Patients under Vitamin D medication werde excluded. Statistical analyses were conducted with Statistica 10.0 (StatSoft). Two-tailed P values of less than 0.05 were considered to indicate statistical significance using student t-test and multiple regression analysis. Hashimoto thyreoiditis (H) and Graves disease (GD) were analysed as different patient groups. Results: 790 females and 90 males each younger than 35 years participated in the study. The age of the patients was 31.5 ± 4.2 (mean ± SE) years, TSH-level (H) 2.1 ± 3.5 (GD under antithyroid medication) 1.3 ± 2.5, parathyroid hormone concentration 27.1 ± 16.7 pg/ml (normal range 10 – 57), 25-hydroxyvitamin- D 17.8 ± 11.8 ng per ml (normal range 8 – 60). The statistical analysis revealed a very high significane for the study population between vitamin D and parathyroid hormone level (p < 0.001) in the student t-test, often seen in vitamin D deficiency. The table shows the significance levels of the parameters in the multiple regression analysis, the tests itself reached the significance level with H p < 0.03 and GD p < 0.0059. variable p-value H significance p-value GD significance Gender 0.02 s. 0.06 Age 0.38 0.39 Volume 0.24 0.27 TSH 0.17 0.02 s. fT4 0.2 0.02 s. TPO 0.303 0.28 TRAK 0.16 0.15 Parathyroid 0.28 0.31 Discussion: In both diseases the Vitamin D concentration was influenced significantly by only few parameter. Thus a significant influence of Viatmin D deficiency on the disease development and progession can be excluded.