From Birth to Death: The Complex Lives of Eukaryotic mRNAs

• Published in: Science (American Association for the Advancement of Science) Vol. 309; no. 5740; pp. 1514 - 1518
• Main Author: Moore, Melissa J
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 02.09.2005; The American Association for the Advancement of Science
• Subjects: Active Transport, Cell Nucleus; Analysis; Animals; Biochemistry; Carrier proteins; Cell Nucleus - metabolism; Cytoplasm; Cytoplasm - metabolism; Cytoplasmic Granules - chemistry; death; Embryology; Eukaryotes; Eukaryotic Cells - metabolism; Gene expression; Gene Expression Regulation; Genes; Messenger RNA; metabolism; MicroRNA; Neurons; Oocytes; Protein Biosynthesis; Proteins; Reviews; Ribonucleic acid; Ribonucleoproteins - metabolism; Ribosomes; RNA; RNA Processing, Post-Transcriptional; RNA stability; RNA, Messenger - analysis; RNA, Messenger - biosynthesis; RNA, Messenger - metabolism; Structure; Transcripts (Written Records); Translation
• ISSN: 0036-8075; 1095-9203; 1095-9203
• DOI: 10.1126/science.1111443

Recent work indicates that the posttranscriptional control of eukaryotic gene expression is much more elaborate and extensive than previously thought, with essentially every step of messenger RNA (mRNA) metabolism being subject to regulation in an mRNA-specific manner. Thus, a comprehensive understanding of eukaryotic gene expression requires an appreciation for how the lives of mRNAs are influenced by a wide array of diverse regulatory mechanisms.