Chemokines as mediators of angiogenesis

Chemokines were originally described as cytokines that mediate leukocyte recruitment to sites of inflammation. Members of a subgroup of chemokines, the CXC family, also play a critical role in both physiologic and pathologic angiogenesis, including in the context of chronic inflammation, fibrosis, a...

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Bibliographic Details
Published inThrombosis and haemostasis Vol. 97; no. 5; p. 755
Main Authors Mehrad, Borna, Keane, Michael P, Strieter, Robert M
Format Journal Article
LanguageEnglish
Published Germany 01.05.2007
Subjects
Animals
Chemokines - physiology
Herpesvirus 8, Human - genetics
Humans
Inflammation - etiology
Inflammation - physiopathology
Mice
Neoplasms, Experimental - blood supply
Neoplasms, Experimental - physiopathology
Neovascularization, Pathologic
Neovascularization, Physiologic
Receptors, Chemokine - genetics
Receptors, Chemokine - physiology
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Summary:Chemokines were originally described as cytokines that mediate leukocyte recruitment to sites of inflammation. Members of a subgroup of chemokines, the CXC family, also play a critical role in both physiologic and pathologic angiogenesis, including in the context of chronic inflammation, fibrosis, and malignancy. A unique feature of this family of cytokines is that, on the basis of their structure and receptor binding, individual ligands display either angiogenic or angiostatic biological activity in the regulation of angiogenesis. In this review, we summarize the key literature in this growing field.
ISSN:0340-6245
DOI:10.1160/TH07-01-0040