Faecal Metaproteomic Analysis Reveals a Personalized and Stable Functional Microbiome and Limited Effects of a Probiotic Intervention in Adults

• Published in: PloS one Vol. 11; no. 4; p. e0153294
• Main Authors: Kolmeder, Carolin A., Salojärvi, Jarkko, Ritari, Jarmo, de Been, Mark, Raes, Jeroen, Falony, Gwen, Vieira-Silva, Sara, Kekkonen, Riina A., Corthals, Garry L., Palva, Airi, Salonen, Anne, de Vos, Willem M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.04.2016; Public Library of Science (PLoS)
• Subjects: Adult; Adults; Analysis; Bacteria; Bacterial Proteins - genetics; Bacterial Proteins - isolation & purification; Bacteriology; Biological activity; Biology; Biology and Life Sciences; Cohort Studies; Computer and Information Sciences; Disease; DNA microarrays; Double-Blind Method; Ethics; Faecalibacterium prausnitzii; Feces - microbiology; Female; Gastrointestinal Microbiome - genetics; Gene expression; Genetic aspects; Genome, Bacterial; Humans; Immunology; Intervention; Intestine; Laboratorium voor Microbiologie; Lactobacillus; Lactobacillus rhamnosus; Longitudinal Studies; Male; Medicine and Health Sciences; Metabolism; Metabolites; Microbiological Laboratory; Microbiologie; Microbiology; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Middle Aged; Nutrition research; Peptide Mapping; Peptides; Phosphatase; Phylogenetics; Phylogeny; Physiological aspects; Precision Medicine; Probiotics; Probiotics - therapeutic use; Proteins; Proteomes; Proteomics; Research and Analysis Methods; RNA, Bacterial - genetics; RNA, Ribosomal, 16S - genetics; Rodents; Spectrometry; Studies; VLAG; WIMEK; Young Adult; Finland; Belgium; Netherlands

Recent metagenomic studies have demonstrated that the overall functional potential of the intestinal microbiome is rather conserved between healthy individuals. Here we assessed the biological processes undertaken in-vivo by microbes and the host in the intestinal tract by conducting a metaproteome...