Evaluation of oxaliplatin exposure of healthcare workers during heated intraperitoneal perioperative chemotherapy (HIPEC)

• Published in: Industrial Health Vol. 53; no. 1; pp. 28 - 37
• Main Authors: VILLA, Antoine F., BALKHI, Souleiman EL, ABOURA, Radia, SAGEOT, Herve, HASNI-PICHARD, Helene, POCARD, Marc, ELIAS, Dominique, JOLY, Nathalie, PAYEN, Didier, BLOT, François, POUPON, Joel, GARNIER, Robert
• Format: Journal Article
• Language: English
• Published: Japan National Institute of Occupational Safety and Health 01.01.2015; National Institute of Occupational Safety and Health, Japan
• Subjects: Adult; Air Pollutants, Occupational - analysis; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - analysis; Antineoplastic Agents - urine; Atmospheric samples; Biomonitoring; Chemotherapy, Cancer, Regional Perfusion; Female; Floors and Floorcoverings; Gloves, Surgical; Hand; Health aspects; HIPEC; Humans; Hyperthermia, Induced; Male; Medical personnel; Middle Aged; Occupational exposure; Occupational Exposure - analysis; Occupational Exposure - prevention & control; Operating Rooms; Operating Tables; Organoplatinum Compounds - administration & dosage; Organoplatinum Compounds - analysis; Organoplatinum Compounds - urine; Original; Oxaliplatin; Peritoneal Neoplasms - surgery; Peritoneal Neoplasms - therapy; Personnel, Hospital; Safety and security measures; Shoes; Surface samples; Young Adult; France
• ISSN: 0019-8366; 1880-8026
• DOI: 10.2486/indhealth.2014-0025

The aim of this study was to evaluate air and surface contaminations, and internal contamination of healthcare workers during open-abdomen HIPEC using oxaliplatin. Platinum (Pt) was measured in urine of exposed workers and in multiple air and surface samples. Three successive HIPEC procedures were investigated in each of the two hospitals participating in the study. Analysis of air samples did not detect any oxaliplatin contamination. Heavy contamination of the operating table, the floor at the surgeon’s feet, and the surgeon’s overshoes were observed. Hand contamination was observed in surgeons using double gloves for intra-abdominal chemotherapy administration, but not in those using three sets of gloves. Pt was not detected in urine samples obtained after HIPEC (<5 ng/L). The main risk of HIPEC is related to direct or indirect skin exposure and can be prevented by correct use of adapted protective equipment.