Action of constituents of Solidago chilensis DC (Brazilian arnica) in the mechanisms of wound healing

• Published in: Planta Medica
• Main Authors: Gastaldo, B, Hatanaka, E, Bortolon, JR, Murata, GM, Bacchi, EM
• Format: Conference Proceeding
• Language: English
• Published: 19.07.2012
• ISSN: 0032-0943; 1439-0221
• DOI: 10.1055/s-0032-1321006

Ersatz of the Arnica montana, Solidago chilensis possess a lagged systematic scientific investigation. To solve the questions about its mechanism of action and considering that neutrophils are involved in inflammatory phase of the wound healing, we investigated the effects of S. chilensis in wound healing process. A wound in the dorsal surface of rats was performed and the lyophilized 70% hydroethanolic extract of S. chilensis (LHEE) were topically administered. On the 5 th day a reduction (52%) of the wound area was verified. In air pouches experiments neutrophil influx was raised 18 times when compared to control and induced a marked increase of IL-1, L-selectin, and IL-6 release. In contrast, it strongly inhibited fMLP-stimulated migration of neutrophils and the amount of cytokines IL-6, L-selectin, IL-1, TNF. In human culture an increase of cytokines liberation was also noticed. We identified the presence of phenolic compounds in the extract, mainly quercitrin which possesses anti-inflammatory activity. Also terpenoids were present. Our results suggest that S. chilensis can regulate accumulation and depletion of neutrophils in the inflammatory foci and may modulate the inflammatory phase of wound healing.