Comparative Nephrotoxicity of Cisplatin and Nedaplatin:Mechanisms and Histopathological Characteristics

The antineoplastic platinum complexes cisplatin and its analogues are widely used in the chemotherapy of a variety of human malignancies, and are especially active against several types of cancers. Nedaplatin is a second-generation platinum complex with reduced nephrotoxicity. However, their use com...

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Published inJournal of Toxicologic Pathology Vol. 24; no. 2; pp. 87 - 94
Main Authors Uehara, Takeki, Yamate, Jyoji, Torii, Mikinori, Maruyama, Toshiyuki
Format Journal Article
LanguageEnglish
Japanese
Published Japan JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY 2011
The Japanese Society of Toxicologic Pathology
Subjects
Cancer
Chemotherapy
Cisplatin
Kidney
Malignancy
nedaplatin
nephrotoxicity
Platinum
renal papilla
Review
Reviews
toxicogenomics
Tumors
kidney
renal papilla
nephrotoxicity
toxicogenomics
cisplatin
nedaplatin
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Summary:The antineoplastic platinum complexes cisplatin and its analogues are widely used in the chemotherapy of a variety of human malignancies, and are especially active against several types of cancers. Nedaplatin is a second-generation platinum complex with reduced nephrotoxicity. However, their use commonly causes nephrotoxicity due to a lack of tumor tissue selectivity. Several recent studies have provided significant insights into the molecular and histopathological events associated with nedaplatin nephrotoxicity. In this review, we summarize findings concerning the renal histopathology and molecular pathogenesis induced by antineoplastic platinum complexes, with a particular focus on the comparative nephrotoxicity of cisplatin and nedaplatin in rats.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0914-9198
1881-915X
1881-915X
DOI:10.1293/tox.24.87