Association between FDG uptake, CSF biomarkers and cognitive performance in patients with probable Alzheimer's disease

• Published in: Pharmacopsychiatry
• Main Authors: Arlt, S, Brassen, S, Wilke, F, Eichenlaub, M, Apostolova, I, Buchert, R, Jahn, H
• Format: Conference Proceeding
• Language: English
• Published: 01.09.2009
• ISSN: 0176-3679; 1439-0795
• DOI: 10.1055/s-0029-1240074

Brain imaging of FDG uptake and cerebrospinal fluid (CSF) concentration of amyloid-beta 1–42 (Aβ1–42) or tau proteins are promising biomarkers in the diagnosis of Alzheimer's disease (AD). There is still uncertainty regarding any association between decreased FDG uptake and alterations in CSF markers. The relationship between FDG uptake, CSFAβ1–42 and total tau (T-tau), as well as the Mini-Mental State Examination (MMSE) score was investigated in 34 subjects with probable AD using step-wise linear regression. FDG uptake was significantly reduced in the probable AD subjects compared to 17 controls bilaterally in the precuneus/posterior cingulate area, angular gyrus/inferior parietal cortex, inferior temporal/midtemporal cortex, midfrontal cortex, and left caudate. Voxel-based single-subject analysis at p<0.001 revealed a total volume of significant hypometabolism ranging from 0 to 452ml (median 70ml) in AD patients. The total hypometabolic volume was negatively correlated with the MMSE score. VOI-based step-wise linear regression revealed that scaled FDG uptake in the precuneus/posterior cingulate was negatively correlated with CSF Aβ1–42. Scaled FDG uptake in the caudate was positively correlated with CSF T-tau. The extent and local severity of the reduction in FDG uptake in probable AD subjects are associated with cognitive impairment. In addition, there appears to be a relationship between local FDG uptake and CSF biomarkers which differs between different brain regions.