Unusual withanolides from Physalis hispida (Waterf.) Cronquist

Withanolides are a group of modified C 28 ergostane-type steroids with a C-22, C-26 δ -lactone side chain. As part of our continuing search for unusual withanolides for SAR studies, we isolated and characterized nine new withanolides (1 – 9), withahisolides A-I, as well as nine known compounds (10 –...

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Bibliographic Details
Published inPlanta Medica
Main Authors Cao, CM, Zhang, H, Gallagher, RJ, Timmermann, BN
Format Conference Proceeding
LanguageEnglish
Published 25.06.2015
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Summary:Withanolides are a group of modified C 28 ergostane-type steroids with a C-22, C-26 δ -lactone side chain. As part of our continuing search for unusual withanolides for SAR studies, we isolated and characterized nine new withanolides (1 – 9), withahisolides A-I, as well as nine known compounds (10 – 18) from the aerial parts of Physalis hispida . The structures of 1 – 9 were elucidated through a variety of spectroscopic techniques, while those of 1 and 2 were further confirmed by X-ray crystallographic analysis. Among the eight new withanolides (1 – 7, 9) with an unusual six-membered ring D, 1 – 3 are the first withanolides possessing non-aromatic six-membered ring D moieties. In addition, withanolide 8 represents a novel withanolide skeleton due to the absence of a C-13-C-17 bond within its steroidal nucleus.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-0035-1556464