Intratumoral Heterogeneity in high grade serous pelvic cancer: Comparing pelvic and omental tumor and lymph node metastases

• Published in: Geburtshilfe und Frauenheilkunde Vol. 75; no. 5
• Main Authors: Meißner, J, Scherlinh, R, Einenkel, J, Höhn, AK, Horn, LC
• Format: Conference Proceeding Journal Article
• Language: English; German
• Published: 09.06.2015
• ISSN: 0016-5751; 1438-8804
• DOI: 10.1055/s-0035-1551620

Background: Recent research has suggested intratumoral heterogeneity in ovarian carcinoma. Additionally, different histologic growth patterns have been described in high grade serous pelvic cancer. Recent definition of molecular subtypes in high grade serous pelvic cancer have suggested that peritumoral desmoplastic response, inflammatory response and proliferative activity (ki-67) as well as the expression of EMA (used as a surrogate marker for MUC-1) may be discriminatory. Methods: Within a preliminary study we have evaluated 12 cases and compared histologic growth pattern, the grade of peritomoral desmoplastic response, inflammatory response (tumor infiltrating lymphocytes; TIL and peritumoral inflammatory response; PER) and immunohistochemical expression of CD 3, EMA, p53 and Ki-67 within pelvic and omental tumor and its lymph node metastases. Results: Eight cases were available for complete analysis. Peritumoral desmoplastic response within the omentum was higher than in pelvic tumor location. Regarding histologic growth pattern, PER/TIL and immunohistochemical expression of CD 3, EMA, p53 and Ki-67 labeling index there were no significant differences between the different tumor locations. Conclusions: Using histologic growth pattern inflammatory response and used immunohistochemical markers (which may surrogate markers for molecular subtyping) there is no intratumoral heterogeneity between tumor locations within the pelvis, the omentum and within lymph node metastases in this preliminary study.