Synthetic tools for studying the chemical biology of InsP 8

To synthesise stabilised mimics of InsP 8 , the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 51; no. 63; pp. 12605 - 12608
Main Authors Riley, Andrew M., Wang, Huanchen, Shears, Stephen B., L. Potter, Barry V.
Format Journal Article
LanguageEnglish
Published 2015
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Summary:To synthesise stabilised mimics of InsP 8 , the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP 8 metabolism.
ISSN:1359-7345
1364-548X
DOI:10.1039/C5CC05017K