SbCl 3 initiated conjunctive C–H bond functionalization and carbochlorination between glycine esters and methylenecyclopropanes (MCPs)
In the presence of dioxygen, an antimony trichloride enabled conjunctive sp 3 C–H bond functionalization and carbochlorination of glycines was realized, providing a series of chlorinated quinolines in high yields. The mechanistic study shows that the antimony( v ) species might be involved in the ox...
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Published in | Chemical communications (Cambridge, England) Vol. 57; no. 77; pp. 9878 - 9881 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
28.09.2021
|
Online Access | Get full text |
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Summary: | In the presence of dioxygen, an antimony trichloride enabled conjunctive sp
3
C–H bond functionalization and carbochlorination of glycines was realized, providing a series of chlorinated quinolines in high yields. The mechanistic study shows that the antimony(
v
) species might be involved in the oxidation of the sp
3
C–H bond and is followed by carbochlorination through a radical intermediate. |
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ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/D1CC03744G |