SbCl 3 initiated conjunctive C–H bond functionalization and carbochlorination between glycine esters and methylenecyclopropanes (MCPs)

In the presence of dioxygen, an antimony trichloride enabled conjunctive sp 3 C–H bond functionalization and carbochlorination of glycines was realized, providing a series of chlorinated quinolines in high yields. The mechanistic study shows that the antimony( v ) species might be involved in the ox...

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Published inChemical communications (Cambridge, England) Vol. 57; no. 77; pp. 9878 - 9881
Main Authors Su, Yichun, Zhang, Shuwei, Yuan, Yuan, Ma, Qiyuan, Sun, Zheng, Yuan, Yu, Jia, Xiaodong
Format Journal Article
LanguageEnglish
Published 28.09.2021
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Summary:In the presence of dioxygen, an antimony trichloride enabled conjunctive sp 3 C–H bond functionalization and carbochlorination of glycines was realized, providing a series of chlorinated quinolines in high yields. The mechanistic study shows that the antimony( v ) species might be involved in the oxidation of the sp 3 C–H bond and is followed by carbochlorination through a radical intermediate.
ISSN:1359-7345
1364-548X
DOI:10.1039/D1CC03744G