Role of MicroRNA in Cardiac Anesthesia: An Innovative Consequences and New Possibility

• Published in: Annals of cardiac anaesthesia Vol. 20; no. 2; pp. 274 - 275
• Main Authors: Barik, Mayadhar, Kumar, Abhay, Mishra, Pravash Ranjan, Kapoor, Poonam Malhotra
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow 01.04.2017; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Edition: 2
• Subjects: Anesthesia; Anesthesia, Cardiac Procedures; Animals; Atherosclerosis; Biomarkers; Cell cycle; Disease; Gene expression; Heart failure; Humans; Ischemia; Letter to Editor; MicroRNA; MicroRNAs; MicroRNAs - physiology; Surgery; Tumor necrosis factor-TNF; India
• ISSN: 0971-9784; 0974-5181
• DOI: 10.4103/aca.ACA_37_16

[...]date, its molecular mechanism and disease progression in human subject poorly understood. [...]therapeutic intervention not yet succeeded among so many diseases. [...]responsible for cardiogenesis, hypertrophic growth response and cardiac conductance as well. Newly emerged miRNA-712 is a potential biomarker and one of the best predictors for arthrosclerosis. [...]cardiovascular disease of the arterial wall associated with lipid retention and inflammation. [...]many number of pro-atherogenic genes including matrix metalloproteinase are also upregulated by d-flow. d-flow mediating pro-inflammatory response and pro-angiogenic signals. [...]24 h, preexisting immature miR-712 formed mature miR-712 suggested that miR-712 is flow-sensitive. [...]miR-712 is add an evidence with TIMP3 decreases the expression of tumor necrosis factor-α (TNF-α) a pro-inflammatory regulator during the turbulent flow. [...]consequences and new possibility in our hand to resolve these diseases through this potential biomarkers. [...]we may also able give new beginning to our future generation through laboratory condition.