Memory consolidation during sleep and adult hippocampal neurogenesis

In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great efforts have been made to utilize neural stem and progenitor cells for regenerative medicine. The capacity of intrinsic neural stem and progenitor cells to regenerate damaged brain tissue remains un...

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Published inNeural regeneration research Vol. 14; no. 1; pp. 20 - 23
Main Authors Koyanagi, Iyo, Akers, Katherine, Vergara, Pablo, Srinivasan, Sakthivel, Sakurai, Takeshi, Sakaguchi, Masanori
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.01.2019
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Japan%Shiffman Medical Library, Wayne State University, Detroit, MI, USA
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
Brain
Brain damage
Health aspects
Hippocampus (Brain)
Homeostasis
Hypotheses
Mammals
Memory
Memory consolidation
Nervous system diseases
Neural networks
Neurogenesis
Neurons
rapid eye movement sleep; sleep deprivation; optogenetics; real-time sleep analysis; hippocampus; fear memory; synaptic plasticity; memory processing
Recall
Review
Sleep
real-time sleep analysis
sleep deprivation
hippocampus
memory processing
fear memory
optogenetics
synaptic plasticity
rapid eye movement sleep
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Summary:In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great efforts have been made to utilize neural stem and progenitor cells for regenerative medicine. The capacity of intrinsic neural stem and progenitor cells to regenerate damaged brain tissue remains unclear, due in part to the lack of knowledge about how these newly born neurons integrate into functional circuitry. As sizable integration of adult-born neurons naturally occurs in the dentate gyrus region of the hippocampus, clarifying the mechanisms of this process could provide insights for applying neural stem and progenitor cells in clinical settings. There is convincing evidence of functional correlations between adult-born neurons and memory consolidation and sleep; therefore, we describe some new advances that were left untouched in our recent review.
Bibliography:ObjectType-Article-2
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Author contributions: All authors wrote the manuscript. MS approved the final manuscript.
The authors contributed equally to the article.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.243695