Medication Use before, during, and after Pregnancy among Women with Eating Disorders: A Study from the Norwegian Mother and Child Cohort Study

• Published in: PloS one Vol. 10; no. 7; p. e0133045
• Main Authors: Lupattelli, Angela, Spigset, Olav, Torgersen, Leila, Zerwas, Stephanie, Hatle, Marianne, Reichborn-Kjennerud, Ted, Bulik, Cynthia M, Nordeng, Hedvig
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.07.2015; Public Library of Science (PLoS)
• Subjects: Adult; Analgesics; Analgesics - administration & dosage; Analysis; Anorexia; Anorexia nervosa; Antidepressants; Anxiolytics; Binge eating disorder; Bulimia; Bulimia nervosa; Cohort analysis; Diagnostic systems; Disorders; Drugs; Eating; Eating disorders; Feeding and Eating Disorders - classification; Feeding and Eating Disorders - epidemiology; Feeding and Eating Disorders - psychology; Female; Gestation; Humans; Laxatives; Laxatives - administration & dosage; Medical research; Medicin och hälsovetenskap; Norway - epidemiology; Postnatal Care; Postpartum; Pregnancy; Pregnant women; Prenatal Care; Psychotropic drugs; Psychotropic Drugs - administration & dosage; Sedatives; Surveys and Questionnaires; Women's health; Womens health; Young Adult; Norway
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0133045

Little is known about medication use among women with eating disorders in relation to pregnancy. To explore patterns of and associations between use of psychotropic, gastrointestinal and analgesic medications and eating disorders in the period before, during and after pregnancy. This study is based on the Norwegian Mother and Child Cohort Study (MoBa). A total of 62,019 women, enrolled at approximately 17 weeks' gestation, had valid data from the Norwegian Medical Birth Registry and completed three MoBa questionnaires. The questionnaires provided diagnostic information on broadly defined anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED) and recurrent self-induced purging in the absence of binge eating (EDNOS-P), along with self-reported use of medication six months before, during, and 0-6 months after pregnancy. The prevalence of eating disorder subtypes before and/or during pregnancy was: 0.09% AN (n = 54), 0.94% BN (n = 585), 0.10% EDNOS-P (n = 61) and 5.00% BED (n = 3104). The highest over-time prevalence of psychotropic use was within the AN (3.7-22.2%) and EDNOS-P (3.3-9.8%) groups. Compared to controls, BN was directly associated with incident use of psychotropics in pregnancy (adjusted RR: 2.25, 99% CI: 1.17-4.32). Having AN (adjusted RR: 5.11, 99% CI: 1.53-17.01) or EDNOS-P (adjusted RR: 6.77, 99% CI: 1.41-32.53) was directly associated with use of anxiolytics/sedatives postpartum. The estimates of use of analgesics (BED) and laxatives (all eating disorders subtypes) were high at all time periods investigated. Use of psychotropic, gastrointestinal, and analgesic medications is extensive among women with eating disorders in the period around pregnancy. Female patients with eating disorders should receive evidence-based counseling about the risk of medication exposure versus the risk of untreated psychiatric illness during pregnancy and postpartum.